Title

Melatonin as a Food Supplement and Drug: Routes of Administration and Formulations

Creator

Voulgari, Nikol-Anna

Abstract

In this Capstone Project, the different routes of administration of melatonin, oral, sublingual, nasal, transdermal, intravenous were explored and compared in terms of effectiveness and bioavailability. The paper concludes that the oral route of administration has a decreased bioavailability of melatonin due to the first-pass metabolism. Furthermore, it was discussed whether melatonin formulations with combined ingredients is a better form of health supplement than that with melatonin as a sole ingredient. Popular ingredients (CBD, ashwagandha, valerian, magnesium and tryptophan) that are added to melatonin supplements in terms of benefits, side effects and interactions were analyzed.

Keywords

melatonin

bioavailability

first-pass effect

Subject

biology

Date Available

June 10, 2024

Type

Poster

Course

BMS 4650 Capstone in Biomedical Sciences

Instructor

Lentis, Dorothea

Session

Poster Display

Location

Student Lounge

Event

Year 2024 | 8th Annual Student Research and Creative Arts Symposium